{"id":9290,"date":"2026-02-12T17:07:33","date_gmt":"2026-02-12T16:07:33","guid":{"rendered":"https:\/\/hemerion.com\/cas-clinique-la-therapie-pentalafen-heliance-mise-en-lumiere-dans-une-publication-scientifique-internationale\/"},"modified":"2026-02-12T18:17:00","modified_gmt":"2026-02-12T17:17:00","slug":"cas-clinique-la-therapie-pentalafen-heliance-mise-en-lumiere-dans-une-publication-scientifique-internationale","status":"publish","type":"post","link":"https:\/\/hemerion.com\/fr\/cas-clinique-la-therapie-pentalafen-heliance-mise-en-lumiere-dans-une-publication-scientifique-internationale\/","title":{"rendered":"Cas clinique : la th\u00e9rapie Pentalafen\/Heliance mise en lumi\u00e8re dans une publication scientifique internationale"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Un \u201ccase report\u201d publi\u00e9 dans le r\u00e9put\u00e9 Journal of Neuro-Oncology Discovery d\u00e9montre \u00e0 nouveau la faisabilit\u00e9, la s\u00e9curit\u00e9 et de la facilit\u00e9 d\u2019int\u00e9gration de la th\u00e9rapie combin\u00e9e Pentalafen\u00ae\/Heliance\u00ae dans le traitement du glioblastome. Ce cas, tir\u00e9 de l&rsquo;essai clinique de phase 1\/2 men\u00e9 par Hemerion au Centre M\u00e9dication de l\u2019Universit\u00e9 de Pittsburgh met en lumi\u00e8re le potentiel de cette technologie \u00e0 red\u00e9finir le paysage du traitement du cancer, en particulier pour les pathologies du syst\u00e8me nerveux central. <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">L&rsquo;obstacle th\u00e9rapeutique majeur dans la lutte contre le glioblastome r\u00e9side dans son caract\u00e8re intrins\u00e8quement invasif. M\u00eame apr\u00e8s une r\u00e9section chirurgicale apparemment compl\u00e8te, la persistance de cellules tumorales r\u00e9siduelles dans le tissu c\u00e9r\u00e9bral adjacent est in\u00e9vitable et entra\u00eene syst\u00e9matiquement une r\u00e9cidive de la tumeur, souvent fatale. <\/p>\n\n<p class=\"wp-block-paragraph\">La mise en \u0153uvre de la technologie Hemerion pour cibler ces cellules r\u00e9siduelles juste apr\u00e8s la r\u00e9section est d\u00e9taill\u00e9e dans un nouveau rapport de cas \u00e9valu\u00e9 par des pairs, dans le Journal of Neuro-Oncology Discovery.<br\/>Cette publication, intitul\u00e9e \u00ab <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s44499-025-00001-4\" target=\"_blank\" rel=\"noreferrer noopener\">Intraoperative photodynamic therapy in glioblastoma: a case report and review of the literature<\/a> \u00bb offre un \u00e9clairage d\u00e9taill\u00e9 sur la technologie Hemerion et ses performances cliniques.<\/p>\n\n<p class=\"wp-block-paragraph\">La th\u00e9rapie Drug-Device d&rsquo;Hemerion combine un photosensibilisateur (Pentalafen\u00ae) et une plateforme d&rsquo;illumination (Heliance\u00ae) qui permet de r\u00e9aliser une phototh\u00e9rapie dynamique perop\u00e9ratoire, imm\u00e9diatement apr\u00e8s l&rsquo;ablation du glioblastome.<\/p>\n\n<p class=\"wp-block-paragraph\">Dans ce cas clinique, le Pentalafen\u00ae a \u00e9t\u00e9 administr\u00e9 quatre heures avant la chirurgie. Ce photosensibilisateur s&rsquo;accumule s\u00e9lectivement dans les cellules canc\u00e9reuses : il est en effet \u00e9limin\u00e9 naturellement dans les cellules saines.  <\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Chirurgie guid\u00e9e par fluorescence :<\/strong> une longueur d&rsquo;onde sp\u00e9cifique est utilis\u00e9e pour provoquer une fluorescence dans les cellules tumorales, ce qui permet de guider plus pr\u00e9cis\u00e9ment la r\u00e9section chirurgicale.<\/li>\n\n\n\n<li><strong>Destruction cibl\u00e9e des cellules canc\u00e9reuses r\u00e9siduelles :<\/strong> une fois la tumeur retir\u00e9e, la plateforme d&rsquo;illumination Heliance\u00ae est d\u00e9ploy\u00e9e pour d\u00e9clencher avec une lumi\u00e8re sp\u00e9cifique une r\u00e9action toxique dans les cellules canc\u00e9reuses r\u00e9siduelles, conduisant \u00e0 leur destruction.<\/li>\n<\/ul>\n\n\t\t<figure class=\"wp-block-jetpack-videopress jetpack-videopress-player\" style=\"\" >\n\t\t\t<div class=\"jetpack-videopress-player__wrapper\"> <iframe title=\"VideoPress Video Player\" aria-label='VideoPress Video Player' width='1200' height='675' src='https:\/\/videopress.com\/embed\/Z9XcsUV0?cover=1&amp;autoPlay=0&amp;controls=1&amp;loop=0&amp;muted=0&amp;persistVolume=1&amp;playsinline=0&amp;preloadContent=metadata&amp;useAverageColor=1&amp;hd=0' frameborder='0' allowfullscreen data-resize-to-parent=\"true\" allow='clipboard-write'><\/iframe><script src='https:\/\/v0.wordpress.com\/js\/next\/videopress-iframe.js?m=1770107250'><\/script><\/div>\n\t\t\t<figcaption><\/figcaption>\n\t\t\t\n\t\t<\/figure>\n\t\t\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<h2 class=\"gb-headline gb-headline-1c93ca17 gb-headline-text\">Des premiers r\u00e9sultats cliniques prometteurs<\/h2>\n\n<p class=\"gb-headline gb-headline-214abc5d gb-headline-text\">Cette publication souligne plusieurs b\u00e9n\u00e9fices essentiels de la th\u00e9rapie combin\u00e9e d&rsquo;Hemerion dans le traitement du glioblastome :<\/p>\n\n<p class=\"wp-block-paragraph\"><strong>Un signe d&rsquo;efficacit\u00e9 potentielle :<\/strong> \u00e0 3 mois de suivi, le patient est rest\u00e9 stable sur le plan neurologique et n&rsquo;a pr\u00e9sent\u00e9 aucun signe de r\u00e9cidive tumorale.<\/p>\n\n<p class=\"wp-block-paragraph\"><strong>Une int\u00e9gration chirurgicale fluide :<\/strong> la description du cas d\u00e9montre la capacit\u00e9 d\u2019Heliance\u00ae \u00e0 int\u00e9grer le protocole chirurgical standard et confirme sa facilit\u00e9 d&rsquo;utilisation en salle d&rsquo;op\u00e9ration. La th\u00e9rapie Hemerion s\u2019est aussi inscrite sans difficult\u00e9 dans le standard de soins, le patient ayant pu d\u00e9marrer sans d\u00e9lai une chimioradioth\u00e9rapie adjuvante (protocole de Stupp). <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>Une s\u00e9curit\u00e9 confirm\u00e9e :<\/strong> la proc\u00e9dure a confirm\u00e9 l&rsquo;excellent profil de s\u00e9curit\u00e9 d\u00e9j\u00e0 observ\u00e9 dans les essais de phase 1\/2 pr\u00e9c\u00e9dents, sans aucun effet secondaire neurologique ind\u00e9sirable signal\u00e9 : un point tr\u00e8s positif pour le lancement du prochain essai clinique.<\/p>\n\n<h2 class=\"gb-headline gb-headline-60d61f7d gb-headline-text\">Une base solide pour le d\u00e9veloppement clinique \u00e0 venir<\/h2>\n\n<p class=\"wp-block-paragraph\">Hemerion se concentre aujourd\u2019hui sur la mise en place des \u00e9tapes cliniques finales pour d\u00e9clencher l&rsquo;autorisation de mise sur le march\u00e9 US, en capitalisant sur ses r\u00e9centes avanc\u00e9es : <a href=\"https:\/\/hemerion.com\/fr\/hemerion-therapeutics-obtient-le-statut-fast-track-de-la-fda-pour-sa-therapie-combinee-pentalafen-heliance-dans-le-traitement-du-glioblastome\/\">d\u00e9signation Fast Track<\/a> et feu vert pour une proc\u00e9dure d\u2019Accelerated Approval obtenus aupr\u00e8s de la FDA ainsi que la collecte de donn\u00e9es de survie tr\u00e8s encourageantes.<br\/>Les essais ant\u00e9rieurs ont notamment montr\u00e9 une survie sans progression (SSP) de 17,1 mois, d\u00e9passant largement les 7 mois g\u00e9n\u00e9ralement atteints par le traitement standard.  <\/p>\n\n<p class=\"wp-block-paragraph\">Cette publication \u00e9valu\u00e9e par des pairs renforce la cr\u00e9dibilit\u00e9 scientifique de la technologie Hemerion. Elle arrive \u00e0 un moment cl\u00e9, au moment o\u00f9 l&rsquo;entreprise pr\u00e9pare son \u00e9tude pivot multicentrique. Elle confirme \u00e9galement \u00e0 la communaut\u00e9 des investisseurs que cette th\u00e9rapie combin\u00e9e est m\u00fbre pour un d\u00e9ploiement clinique \u00e0 grande \u00e9chelle.  <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un \u201ccase report\u201d publi\u00e9 dans le r\u00e9put\u00e9 Journal of Neuro-Oncology Discovery d\u00e9montre \u00e0 nouveau la faisabilit\u00e9, la s\u00e9curit\u00e9 et de la facilit\u00e9 d\u2019int\u00e9gration de la th\u00e9rapie combin\u00e9e Pentalafen\u00ae\/Heliance\u00ae dans le traitement du glioblastome. Ce cas, tir\u00e9 de l&rsquo;essai clinique de phase 1\/2 men\u00e9 par Hemerion au Centre M\u00e9dication de l\u2019Universit\u00e9 de Pittsburgh met en lumi\u00e8re &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"Cas clinique : la th\u00e9rapie Pentalafen\/Heliance mise en lumi\u00e8re dans une publication scientifique internationale\" class=\"read-more button\" href=\"https:\/\/hemerion.com\/fr\/cas-clinique-la-therapie-pentalafen-heliance-mise-en-lumiere-dans-une-publication-scientifique-internationale\/#more-9290\" aria-label=\"En savoir plus sur Cas clinique : la th\u00e9rapie Pentalafen\/Heliance mise en lumi\u00e8re dans une publication scientifique internationale\">Lire plus<\/a><\/p>\n","protected":false},"author":207845438,"featured_media":9288,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_jet_sm_ready_style":"","_jet_sm_style":"","_jet_sm_controls_values":"","_jet_sm_fonts_collection":"","_jet_sm_fonts_links":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[6342],"tags":[],"class_list":["post-9290","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cas clinique : la th\u00e9rapie Pentalafen\/Heliance mise en lumi\u00e8re dans une publication scientifique internationale - Hemerion<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hemerion.com\/fr\/cas-clinique-la-therapie-pentalafen-heliance-mise-en-lumiere-dans-une-publication-scientifique-internationale\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cas clinique : la th\u00e9rapie Pentalafen\/Heliance mise en lumi\u00e8re dans une publication scientifique internationale - Hemerion\" \/>\n<meta property=\"og:description\" content=\"Un \u201ccase report\u201d publi\u00e9 dans le r\u00e9put\u00e9 Journal of Neuro-Oncology Discovery d\u00e9montre \u00e0 nouveau la faisabilit\u00e9, la s\u00e9curit\u00e9 et de la facilit\u00e9 d\u2019int\u00e9gration de la th\u00e9rapie combin\u00e9e Pentalafen\u00ae\/Heliance\u00ae dans le traitement du glioblastome. Ce cas, tir\u00e9 de l&rsquo;essai clinique de phase 1\/2 men\u00e9 par Hemerion au Centre M\u00e9dication de l\u2019Universit\u00e9 de Pittsburgh met en lumi\u00e8re ... 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Hemerion","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/hemerion.com\/fr\/cas-clinique-la-therapie-pentalafen-heliance-mise-en-lumiere-dans-une-publication-scientifique-internationale\/","og_locale":"fr_FR","og_type":"article","og_title":"Cas clinique : la th\u00e9rapie Pentalafen\/Heliance mise en lumi\u00e8re dans une publication scientifique internationale - Hemerion","og_description":"Un \u201ccase report\u201d publi\u00e9 dans le r\u00e9put\u00e9 Journal of Neuro-Oncology Discovery d\u00e9montre \u00e0 nouveau la faisabilit\u00e9, la s\u00e9curit\u00e9 et de la facilit\u00e9 d\u2019int\u00e9gration de la th\u00e9rapie combin\u00e9e Pentalafen\u00ae\/Heliance\u00ae dans le traitement du glioblastome. 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